NewBeauty Facebook Pinterest Instagram Youtube find a doctor Face Adult Acne Antioxidants Anti-Aging Celebrity Chronic Skin Conditions Eye Hydration Hyperpigmentation Makeup View All Eyebrows Eye Color Foundation Fragrance Lip Color Makeovers Male Skin Care Peels Pre-Event Prep Sensitive Skin Skin Care Skin Health Smile Sun Care Treatments Fillers Microneedling Post-Procedure Skin Care Neurotoxins Regenerative Aesthetics Skin Lifting Body Body Sculpting Breasts Butts Cellulite Hair Removal Hands + Nails Legs Pregnancy Find a Doctor Hair Bond Repair Celebrity Dry Hair Frizzy Hair Gray Hair Hair Color Hair Growth Hair Repair Scalp Health Styling + Tips Awards NB100 Awards 15th Annual Beauty Awards 2025 NewBeauty Readers’ Choice Awards Shopping Gift Guides Product Reviews NewBeauty Storefront Wellness Fitness GLP-1s Health Menopause About Us TESTTUBE Search for: Search HomeCosmetic TreatmentsNeurotoxins The Ultimate Guide to Neurotoxins for Mature Skin What to know about dosing, treatment areas and what really works after 40. Tatiana Bido Published: Nov 18, 2025 5./15 WEST/ Getty Images In This Article Featured ExpertsWhy Less Is Sometimes More With Mature SkinWhere Neurotoxin Makes the Biggest Difference With Mature SkinWhat Not to Do Neurotoxins are still one of the most effective ways to look refreshed, but experts agree the technique should evolve as the face matures. Houston dermatologist Jennifer Segal, MD, explains that “as we age, the skin naturally thins and loses elasticity,” meaning traditional areas like the forehead may require more finesse to lift and brighten the eyes. Omaha dermatologist Joel Schlessinger, MD, notes changes deeper in the facial structure as well. “Our muscles generally lose strength over time and can lead to differences in facial expression,” he says. To prevent a flat look or dropped brow, he often lowers dosing to match what the face actually needs. As anatomy shifts, so should technique. Ahead, dermatologists break down why less is often…

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