The GLP-1 Medications You’ll Be Hearing About Next
NewBeauty Facebook Pinterest Instagram Youtube find a doctor Face Adult Acne Antioxidants Anti-Aging Celebrity Chronic Skin Conditions Eye Hydration Hyperpigmentation Makeup View All Eyebrows Eye Color Foundation Fragrance Lip Color Makeovers Male Skin Care Peels Pre-Event Prep Sensitive Skin Skin Care Skin Health Smile Sun Care Treatments Fillers Microneedling Post-Procedure Skin Care Neurotoxins Regenerative Aesthetics Skin Lifting Body Body Sculpting Breasts Butts Cellulite Hair Removal Hands + Nails Legs Pregnancy Find a Doctor Hair Bond Repair Celebrity Dry Hair Frizzy Hair Gray Hair Hair Color Hair Growth Hair Repair Scalp Health Styling + Tips Awards NB100 Awards 15th Annual Beauty Awards 2025 NewBeauty Readers’ Choice Awards Shopping Gift Guides Product Reviews NewBeauty Storefront Wellness Fitness GLP-1s Health Menopause About Us TESTTUBE Search for: Search HomeWellnessGLP-1s The GLP-1 Medications You’ll Be Hearing About Next What experts say is coming up next. Originally Published on Dermatology Times Published: Dec 22, 2025 Getty Images / Peter Dazeley GLP-1s are everywhere right now—from doctors’ offices to dinner-party conversations—but most of the attention has focused on just a few familiar names. Behind the scenes, however, a new generation of GLP-1 medications is moving through clinical trials, with oral options, combination therapies and strong early results. Ahead, we’re breaking down the GLP-1 agonists being studied for weight-loss treatment that you’re likely to hear more about next, how they work in the body and what sets each one apart, drawing from a guide originally published by Pharmacy Times. Orforglipron is a first-in-class, nonpeptide oral GLP-1 receptor agonist. It differs from injectable GLP-1 agents in its composition. Unlike peptide-based formulations made of amino acid chains, orforglipron is a small-molecule compound, allowing it to remain stable and effective in the acidic environment of the stomach. Orforglipron is taken orally once daily and there is no requirement for fasting.