Is This the First Truly Non-Irritating Retinoid?
NewBeauty Facebook Pinterest Instagram Youtube find a doctor Face Adult Acne Antioxidants Anti-Aging Celebrity Chronic Skin Conditions Eye Hydration Hyperpigmentation Makeup View All Eyebrows Eye Color Foundation Fragrance Lip Color Makeovers Male Skin Care Peels Pre-Event Prep Sensitive Skin Skin Care Skin Health Smile Sun Care Treatments Fillers Microneedling Post-Procedure Skin Care Neurotoxins Regenerative Aesthetics Skin Lifting Body Body Sculpting Breasts Butts Cellulite Hair Removal Hands + Nails Legs Pregnancy Find a Doctor Hair Bond Repair Celebrity Dry Hair Frizzy Hair Gray Hair Hair Color Hair Growth Hair Repair Scalp Health Styling + Tips Awards NB100 Awards 15th Annual Beauty Awards 2025 NewBeauty Readers’ Choice Awards Shopping Gift Guides Product Reviews NewBeauty Storefront Wellness Fitness GLP-1s Health Menopause About Us TESTTUBE Search for: Search HomeFaceSkin Care Is This the First Truly Non-Irritating Retinoid? The data says yes. Danielle Fontana Dooley Published: Feb 27, 2026 We may earn commission from links on this page. Each product featured has been vetted and chosen by our editors. Kateryna Klishchevnik / Getty Images Retinoids are the gold standard for anti-aging—but they come with a catch. The redness, peeling and sensitivity that often accompany them can be enough to make even the most dedicated skin-care enthusiasts throw in the towel. Now, a new clinical study published in the Journal of Cosmetic Dermatology suggests there might be a way around that. The 12-week study looked at HYDRINITY’s RetaXome Daily Retinal Hydrator, which uses retinal (a potent form of vitamin A) encapsulated in what the brand calls “biomimetic exosomes”—essentially, a delivery system designed to get the ingredient into skin more effectively while minimizing irritation. 20 women between 35 and 65 with mild-to-moderate sun damage applied the product nightly, and researchers tracked improvements in redness, skin tone, texture and fine lines. The results: Redness dropped by 68 percent…