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The First Psoriasis Pill That Could Rival Injectables Is Here

The First Psoriasis Pill That Could Rival Injectables Is Here

NewBeauty Facebook Pinterest Instagram Youtube find a doctor Face Adult Acne Antioxidants Anti-Aging Celebrity Chronic Skin Conditions Eye Hydration Hyperpigmentation Makeup View All Eyebrows Eye Color Foundation Fragrance Lip Color Makeovers Male Skin Care Peels Pre-Event Prep Retinoids Sensitive Skin Skin Care Skin Health Smile Sun Care Treatments Fillers Microneedling Post-Procedure Skin Care Neurotoxins Regenerative Aesthetics Skin Lifting Body Body Sculpting Breasts Butts Cellulite Hair Removal Hands + Nails Legs Pregnancy Find a Doctor Hair Bond Repair Celebrity Dry Hair Frizzy Hair Gray Hair Hair Color Hair Growth Hair Repair Scalp Health Styling + Tips Awards NB100 Awards 15th Annual Beauty Awards 2025 NewBeauty Readers’ Choice Awards Shopping Gift Guides Product Reviews NewBeauty Storefront Wellness Fitness GLP-1s Health Menopause About Us TESTTUBE Search for: Search HomeFaceSkin Care The First Psoriasis Pill That Could Rival Injectables Is Here A closer look at ICOTYDE, including how it works and who it’s for. Tatiana Bido Published: Mar 25, 2026 Getty Images / Galina Zhigalova For years, the most effective psoriasis treatments have come in the form of injections. Now, there is a new option that may feel a little easier for some to commit to. The FDA has approved ICOTYDE (icotrokinra), a once-daily pill for moderate-to-severe plaque psoriasis that targets the same IL-23 pathway as today’s leading injectables. It’s the first time this level of targeted therapy has been available in an oral form, giving patients the possibility of skipping needles without giving up results. ICOTYDE works differently than older oral medications. It is an oral peptide designed to survive the digestive system and reach its target. “This is the first oral peptide of its kind designed to enhance absorption from the gastrointestinal tract while targeting a pathway in the pathogenesis of psoriasis,” says Detroit dermatologist Linda Stein Gold, MD. It blocks the…

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