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Isotretinoin, But Make It Topical: This Accutane Alternative Just Made Acne Care More Accessible

Isotretinoin, But Make It Topical: This Accutane Alternative Just Made Acne Care More Accessible

My AccountFIND A DOCTORFaceAdult AcneAnti-AgingAntioxidantsCelebrityChronic Skin ConditionsEyeHydrationHyperpigmentationMakeupMale Skin CarePeelsPre-Event PrepRetinoidsSensitive SkinSkin CareSkin HealthSmileSun CareTreatmentsAnti-WrinkleFillersMicroneedlingNeurotoxinsPost-Procedure Skin CareRegenerative AestheticsBodyBody SculptingBreastsButtsCelluliteFind a DoctorHair RemovalHands + NailsLegsPregnancyHairBond RepairCelebrity HairDry HairFrizzy HairGray HairHair ColorHair GrowthHair RepairScalp HealthTips + TutorialsAwardsNB100 Awards16th Annual Beauty Awards2025 NewBeauty Readers’ Choice AwardsShoppingBeautyReportGift GuidesNewBeauty StorefrontProduct ReviewsWellnessFitnessGLP-1sHealthMenopauseAbout UsTESTTUBEFaceView All FaceAdult AcneAnti-AgingAntioxidantsCelebrityChronic Skin ConditionsEyeHydrationHyperpigmentationMakeupMale Skin CarePeelsPre-Event PrepRetinoidsSensitive SkinSkin CareSkin HealthSmileSun CareTreatmentsView All TreatmentsAnti-WrinkleFillersMicroneedlingNeurotoxinsPost-Procedure Skin CareRegenerative AestheticsBodyView All BodyBody SculptingBreastsButtsCelluliteFind a DoctorHair RemovalHands + NailsLegsPregnancyHairView All HairBond RepairCelebrity HairDry HairFrizzy HairGray HairHair ColorHair GrowthHair RepairScalp HealthTips + TutorialsAwardsView All AwardsNB100 Awards16th Annual Beauty Awards2025 NewBeauty Readers’ Choice AwardsShoppingView All ShoppingBeautyReportGift GuidesNewBeauty StorefrontProduct ReviewsWellnessView All WellnessFitnessGLP-1sHealthMenopauseAbout UsLoading…FIND A DOCTORTESTTUBE Advertisement Home›Face›Adult Acne Isotretinoin, But Make It Topical: This Accutane Alternative Just Made Acne Care More Accessible This could change how millions of acne sufferers approach treatment. Anyone who has tried to get Accutane knows the drill: monthly pregnancy tests, two forms of birth control, a seven-day pharmacy pickup window and a bureaucratic program called iPLEDGE that has been known to lock patients out of their prescriptions over a missed click. Now, as reported by Dermatology Times, Clear Health is offering a way around all of it. The telehealth skin-care platform just launched Isoclear, a prescription topical acne treatment using isotretinoin—the active ingredient in oral Accutane—delivered through a 3-phase compounded regimen. Unlike oral isotretinoin, which requires enrollment in the iPLEDGE risk management program and ongoing laboratory monitoring, Isoclear is formulated as a topical treatment by licensed US compounding pharmacies. Because it is a compounded topical product, it falls entirely outside the iPLEDGE system. The company positions the approach as a more accessible alternative for patients who are candidates for isotretinoin therapy but may be hesitant to pursue the oral formulation, including women of childbearing potential.

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