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Jamie-Lynn Sigler Opens Up About MS, Her Memoir and Why She Finally Opened Her DMs

My AccountFIND A DOCTORFaceAdult AcneAnti-AgingAntioxidantsCelebrityChronic Skin ConditionsEyeHydrationHyperpigmentationMakeupMale Skin CarePeelsPre-Event PrepRetinoidsSensitive SkinSkin CareSkin HealthSmileSun CareTreatmentsFillersMicroneedlingNeurotoxinsPost-Procedure Skin CareRegenerative AestheticsSkin Lifting and TighteningBodyBody SculptingBreastsButtsCelluliteFind a DoctorHair RemovalHands + NailsLegsPregnancyHairBond RepairCelebrity HairDry HairFrizzy HairGray HairHair ColorHair GrowthHair RepairScalp HealthTips + TutorialsAwardsNB100 Awards16th Annual Beauty Awards2025 NewBeauty Readers’ Choice AwardsShoppingBeautyReportGift GuidesNewBeauty StorefrontProduct ReviewsWellnessFitnessGLP-1sHealthMenopauseAbout UsTESTTUBEFaceView All FaceAdult AcneAnti-AgingAntioxidantsCelebrityChronic Skin ConditionsEyeHydrationHyperpigmentationMakeupMale Skin CarePeelsPre-Event PrepRetinoidsSensitive SkinSkin CareSkin HealthSmileSun CareTreatmentsView All TreatmentsFillersMicroneedlingNeurotoxinsPost-Procedure Skin CareRegenerative AestheticsSkin Lifting and TighteningBodyView All BodyBody SculptingBreastsButtsCelluliteFind a DoctorHair RemovalHands + NailsLegsPregnancyHairView All HairBond RepairCelebrity HairDry HairFrizzy HairGray HairHair ColorHair GrowthHair RepairScalp HealthTips + TutorialsAwardsView All AwardsNB100 Awards16th Annual Beauty Awards2025 NewBeauty Readers’ Choice AwardsShoppingView All ShoppingBeautyReportGift GuidesNewBeauty StorefrontProduct ReviewsWellnessView All WellnessFitnessGLP-1sHealthMenopauseAbout UsLoading…FIND A DOCTORTESTTUBE Advertisement Home›Celebrity Jamie-Lynn Sigler Opens Up About MS, Her Memoir and Why She Finally Opened Her DMs She's done staying silent. Liz RitterInstagramAbout NewBeauty Jun 4, 2026 Novartis Best known for her breakout role in The Sopranos, Jamie-Lynn Sigler has spent the past 25 years navigating life with relapsing multiple sclerosis (RMS)—a diagnosis she kept largely private for more than a decade. Now, she’s stepping fully into her story with a deeply personal new memoir, pulling back the curtain on her journey, from brushing off her symptoms on set to learning how to set boundaries, ask for help and advocate for herself. Beyond her own healing, Sigler is channeling that hard-won confidence into something bigger. Through a collaboration with Novartis, she’s become a passionate advocate for others living with RMS, encouraging them to find their voice and communicate their needs—a message that carries through everything she does. With new projects on the horizon, Sigler is proving her most compelling chapter may be the one she’s writing now.

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